MOLECULAR-BIOLOGY OF BREAST-CARCINOMA

During the last several years basic research has resulted in the ident ification of many of the factors involved in signal transduction pathw ays, leading us to a greater understanding of the mechanisms of growth control in breast cancer cells. Many of these factors are the product s of proto-oncogenes or suppressor genes. This review describes the ro le of some of these factors in breast cancer development, progression, and metastasis and discusses implications for future directions.