APPLICATION OF RADIORECEPTOR ASSAYS FOR SYSTEMATIC TOXICOLOGICAL ANALYSIS .1. PROCEDURES FOR RADIORECEPTOR ASSAYS FOR ANTIHISTAMINICS, ANTICHOLINERGICS AND BENZODIAZEPINES

Radioreceptor assays can be a useful tool for systematic toxicological analysis in that they can be applied for the detection of an entire p harmacological class of drugs. In the present paper procedures for rad ioreceptor assays for benzodiazepines, anticholinergics and antihistam inics have been described in detail. The development of the assay for antihistaminics in urine is given in order to illustrate the prerequis ites for these types of assays with regard to the incubation condition s. In part 2 the applicability of the three assays for systematic toxi cological analysis will be evaluated on the basis of testing a large n umber of urine samples after administration of a selected number of dr ugs to healthy volunteers and patients.