ISOLATION AND IDENTIFICATION OF A FK-506 C-36-C-37 DIHYDRODIOL FROM ERYTHROMYCIN-INDUCED RABBIT LIVER-MICROSOMES

Authors
LHOEST G MATON N LAURENT A VERBEECK RK
Citation
G. Lhoest et al., ISOLATION AND IDENTIFICATION OF A FK-506 C-36-C-37 DIHYDRODIOL FROM ERYTHROMYCIN-INDUCED RABBIT LIVER-MICROSOMES, Journal of pharmaceutical and biomedical analysis, 12(2), 1994, pp. 235-241
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
12
Issue
2
Year of publication
1994
Pages
235 - 241
Database
ISI
SICI code
0731-7085(1994)12:2<235:IAIOAF>2.0.ZU;2-J
Abstract
A new metabolite of FK-506 extracted from erythromycin-induced rabbit liver microsomes, isolated by normal- and reversed-phase HPLC chromato graphy, identified by FAB mass spectrometry and NMR spectroscopy is de scribed.