H. Rautelin et al., RIBOTYPING PATTERNS AND EMERGENCE OF METRONIDAZOLE RESISTANCE IN PAIRED CLINICAL-SAMPLES OF HELICOBACTER-PYLORI, Journal of clinical microbiology, 32(4), 1994, pp. 1079-1082
Metronidazole-susceptible pretreatment isolates and metronidazole-resi
stant posttreatment isolates of Helicobacter pylori from 11 patients b
efore and after unsuccessful triple therapy consisting of metronidazol
e, amoxicillin, and colloidal bismuth subcitrate were studied. Ribotyp
ing (rRNA gene restriction pattern analysis) of the isolates demonstra
ted that all patients except one had identical digest patterns for pre
- and posttreatment isolates.