ATYPICAL PROGRESSION OF MULTIPLE-MYELOMA WITH EXTENSIVE EXTRAMEDULLARY DISEASE

Multiple myeloma is a neoplastic disorder caused by the proliferation of a transformed B lymphoid progenitor cell that gives rise to a clone of immunoglobulin-secreting cells. Other plasma cell tumours include solitary plasmacytoma of bone (SPB) and extramedullary plasmacytomas ( EMP). Despite an apparent common origin there exist pathological and c linical differences between these neoplasms and the association betwee n them is not completely understood. A case of IgG multiple myeloma th at presented with typical clinical and laboratory features, including a bone marrow infiltrated by well. differentiated plasma cells, is rep orted. The tumour had an unusual evolution, with the development of ex tensive extramedullary disease while maintaining mature histological f eatures.