Sn. Jowitt et al., ATYPICAL PROGRESSION OF MULTIPLE-MYELOMA WITH EXTENSIVE EXTRAMEDULLARY DISEASE, Journal of Clinical Pathology, 47(3), 1994, pp. 269-271
Multiple myeloma is a neoplastic disorder caused by the proliferation
of a transformed B lymphoid progenitor cell that gives rise to a clone
of immunoglobulin-secreting cells. Other plasma cell tumours include
solitary plasmacytoma of bone (SPB) and extramedullary plasmacytomas (
EMP). Despite an apparent common origin there exist pathological and c
linical differences between these neoplasms and the association betwee
n them is not completely understood. A case of IgG multiple myeloma th
at presented with typical clinical and laboratory features, including
a bone marrow infiltrated by well. differentiated plasma cells, is rep
orted. The tumour had an unusual evolution, with the development of ex
tensive extramedullary disease while maintaining mature histological f
eatures.