Ga. Harshfield et al., AMBULATORY BLOOD-PRESSURE AND RENAL-FUNCTION IN HEALTHY-CHILDREN AND ADOLESCENTS, American journal of hypertension, 7(3), 1994, pp. 282-285
Our previous studies using noninvasive ambulatory blood pressure (ABP)
monitoring demonstrated racial differences in the diurnal pattern of
blood pressure (BP), with higher nighttime BP for African-Americans th
an for Angle-Americans despite similar daytime BP. We have hypothesize
d that the increased BP load in African-Americans contributes to the i
ncreased prevalence of hypertension and BP-induced target organ damage
in adults. The purpose of this study was to examine the relationship
between ABP patterns and renal function in healthy, normotensive black
and white youths. The subjects were 22 African-American and 28 Angle-
American children and adolescents aged 10 to 18 years. Renal function
was estimated by creatinine clearance (C-Cr). The African-American and
Angle-American subjects were similar in age, gender composition, casu
al BP, and C-r, The relationship between C-Cr and BP was not significa
nt for casual BP or daytime BP for either group, or with nighttime BP
in the Angle-American subjects. In contrast, C-Cr was related negative
ly to both nighttime systolic BP (r = -0.47, beta = -1.21; P <.02) and
nighttime diastolic BP in the African-American subjects (r = -0.45, b
eta = -2.13; P <.03). These results are consistent with our hypothesis
.