We discuss the expected evolution of X-ray clusters of galaxies in dif
ferent models for structure formation: these are cold dark matter, hyb
rid, and baryonic isocurvature models. We compare the theoretical pred
ictions with the observed X-ray local luminosity function and with the
counts obtained from the Extended Medium Sensitivity Survey (EMSS) of
the HEAO 2 satellite. For properly comparing our predictions with the
EMSS data we apply several corrections to the theoretical X-ray lumin
osities and fluxes. We find that the most effective correction comes f
rom considering the finite size of the EMSS detection cell in the HEAO
2 Imaging Proportional Counter cluster images. The available X-my dat
a are extremely selective. They allow to reject baryonic isocurvature
models, as well as hybrid models where hot dark matter provides approx
imately 30% of the critical density. The model which performs by far b
etter than the others considered here is a low-density (OMEGA0 = 0.2 h
= 0.75) vacuum-dominated cold dark matter model with an initial scale
-free density fluctuation spectrum. In all models, the brighter X-ray
clusters are rare objects originating from the high peaks of the initi
al density field. This implies that optical galaxies are biased tracer
s of the mass density field, unless the cluster collapse occurs on tim
escales longer than those of the ideal pressureless sphere. We discuss
our results in the light of the COBE-DMR detection of large scale ani
sotropy of the cosmic microwave background.