THYMIDINE KINASE-ACTIVITY IN LIVER AND SERUM OF RATS AFTER CADMIUM ADMINISTRATION

Authors
THEOCHARIS SE MARGELI AP ALEVIZOU V VARONOS D
Citation
Se. Theocharis et al., THYMIDINE KINASE-ACTIVITY IN LIVER AND SERUM OF RATS AFTER CADMIUM ADMINISTRATION, Toxicology letters, 71(1), 1994, pp. 1-7
Citations number
26
Categorie Soggetti
Toxicology
Journal title
Toxicology letters → ACNP
ISSN journal
03784274
Volume
71
Issue
1
Year of publication
1994
Pages
1 - 7
Database
ISI
SICI code
0378-4274(1994)71:1<1:TKILAS>2.0.ZU;2-J
Abstract
Intraperitoneal administration of a cadmium (Cd) salt at concentration s of 2.5 and 4.0 mg CdCl2/kg of body wt., caused time-dependent severe liver injury, in Quinster rats, more intense at the higher administer ed dose. Thymidine kinase, the key enzyme of the salvage pathway of DN A biosynthesis, was strongly affected in liver tissue and serum of cad mium-intoxicated rats. Lower thymidine kinase activity was observed bo th in liver and serum of rats treated with the higher dose of cadmium, in which the maximal liver injury appeared.