THE HUMAN TESTICULE DETERMINING FACTOR - FROM THE GENE TO THE PROTEIN

Since its cloning in 1990, the human SRY gene has been formally identi fied with the testis determining factor. The SRY gene encodes a 204 am ino acid protein of the High Mobility Group family. Its ability to bin d DNA, to bend DNA or to be translocated into the nuclear compartment of the cell have now been established. However, neither its mode of ac tion nor the description of target genes have been described so far, a nd are the topics of many studies.