NEW INSIGHTS INTO THE MAN-MOUSE COMPARATIVE MAP OF THE X-CHROMOSOME

Two conserved loci, DXHX674h and DXHX679h, which map to Xp11.22--Xp11. 21 on the human X chromosome short arm, have been positioned between t he loci for proteolipid protein (Pip) and the Ela subunit of pyruvate dehydrogenase (Pdha1) in the distal region of the mouse X chromosome u sing Mus musculus x Mus spretus interspecific backcrosses. These data, together with previous comparative mapping studies on another conserv ed locus (DXF34) and the locus that encodes the erythroid transcriptio n factor (GATA1), reveal that loci that map to the proximal region of the human X chromosome short arm lie in four different regions of the mouse X chromosome and that the human and mouse X chromosomes contain a minimum of eight conserved segments. (C) 1994 Academic Press, Inc.