BUPIVACAINE KINETICS DURING HYPERTHERMIA IN RATS

Citation
B. Bruguerolle et al., BUPIVACAINE KINETICS DURING HYPERTHERMIA IN RATS, Canadian journal of anaesthesia, 41(3), 1994, pp. 253-256
Citations number
18
Categorie Soggetti
Anesthesiology
ISSN journal
0832610X
Volume
41
Issue
3
Year of publication
1994
Pages
253 - 256
Database
ISI
SICI code
0832-610X(1994)41:3<253:BKDHIR>2.0.ZU;2-V
Abstract
The aim of this study was to document possible alterations of bupivaca ine pharmacokinetic behaviour in rats during hyperthermia. Two groups of Wistar AF IOPS male rats (Group A = normothermic controls, Group B = hyperthermia-induced animals) received a single 20 mg.kg(-1) ip dose of bupivacaine. Two other groups (Group C = normothermic controls wit hout bupivacaine, Group D = hyperthermia-induced animals without bupiv acaine) received, under the same experimental conditions, an equivalen t volume of saline. Hyperthermia-induced animals (Groups B and D) were placed in a water-bath at 40 degrees C. Bupivacaine or saline were ad ministered (Group B and D) four hours after the beginning of the exper iment and blood samples were obtained by retro-orbital sinus puncture 0.25, 0.5, 1, 2, 4 and 8 hr after administration. Bupivacaine and its main metabolite, 2,6 desbutylbupivacaine (PPX) were assayed according to a gas liquid chromatographic method. The Cmax, Tmax, t(1/2), Cl, Vd and AUC were determined according to a two compartment open model. Ou r data have demonstrated a decrease in clearance of bupivacaine (5.85 +/- 0.23 ml.hr(-1) and 4.59 +/- 0.35 ml.hr(-1) for groups A and B, res pectively, P < 0.05, and Tmax of PPX during hyperthermia (0.25 +/- 0.0 3 hr and 0.15 +/- 0.0 hr for Groups A and B, respectively, P < 0.05). In conclusion, hyperthermia induces a decrease in bupivacaine clearanc e in rats which may be of importance in clinical practice.