PHARMACOKINETICS OF N-METHYLGLUCAMINE ANTIMONIATE AFTER INTRAVENOUS, INTRAMUSCULAR AND SUBCUTANEOUS ADMINISTRATION IN THE DOG

Authors
TASSI P ORMAS P MADONNA M CARLI S BELLOLI C DENATALE G CECI L MARCOTRIGIANO GO
Citation
P. Tassi et al., PHARMACOKINETICS OF N-METHYLGLUCAMINE ANTIMONIATE AFTER INTRAVENOUS, INTRAMUSCULAR AND SUBCUTANEOUS ADMINISTRATION IN THE DOG, Research in Veterinary Science, 56(2), 1994, pp. 144-150
Citations number
16
Categorie Soggetti
Veterinary Sciences
Journal title
Research in Veterinary Science → ACNP
ISSN journal
00345288
Volume
56
Issue
2
Year of publication
1994
Pages
144 - 150
Database
ISI
SICI code
0034-5288(1994)56:2<144:PONAAI>2.0.ZU;2-V
Abstract
The pharmacokinetic profile of antimony in dogs was defined by adminis tering it intravenously, intramuscularly and subcutaneously as N-methy lglucamine antimoniate at a dose of about 25.65 mg of antimony kg(-1) bodyweight. The results showed a different half-life for the three rou tes of administration: 20.5, 42.1 and 121.6 minutes for the intravenou s, intramuscular and subcutaneous routes, respectively; peak time valu es (T-max) were also different for the intramuscular (90 to 120 minute s) and subcutaneous (210 to 240 minutes) injection. The apparent bioav ailability of antimony was >100 per cent for the intramuscular and 100 per cent for the subcutaneous routes. The data obtained showed a rele vant difference in the behaviour of the drug in the dog in comparison to that in humans.