RELATION BETWEEN GASTRIC-EMPTYING OF ALBUMIN-DEXTROSE MEALS AND CHOLECYSTOKININ RELEASE IN MAN

The effect of intragastric dextrose on albumin-stimulated cholecystoki nin (CCK) release was studied in five healthy subjects and was related to gastric emptying and pancreatobiliary secretions. When combined wi th low concentrations of dextrose (4 g/100 ml), a 500-ml solution of a lbumin (7 g/100 ml) was rapidly emptied from the stomach into the duod enum (T1/2: 35 min). This rapid gastric emptying resulted in an only t ransient stimulation of pancreatobiliary secretion and an integrated C CK release of 278 +/- 45 pM x 180 min. When the concentration of dextr ose in the albumin solution was increased from 4 g/100 ml to 21 g/100 ml, gastric emptying rate was distinctly slower (T1/2: 78 min; P < 0.0 1) and pancreatobiliary secretions became sustained (P < 0.01). CCK re lease was markedly higher (900 +/- 421 pM x 180 min; P < 0.05) after i ngestion of the solution containing a high dextrose concentration. Int raduodenal infusion of 21 g/100 ml dextrose (3.1 ml/min) failed to sig nificantly stimulate plasma CCK levels (119 +/- 38 pM x 120 min). We s uggest that the higher CCK release in response to intragastrically adm inistered albumin solution containing high concentrations of dextrose may have been induced by augmented peptic digestion of albumin due to delayed gastric emptying and by increased enteral digestion of albumin due to increased pancreatobiliary outputs.