I. Belcheva et al., HIPPOCAMPAL ASYMMETRY IN THE BEHAVIORAL-RESPONSES TO THE 5-HT1A RECEPTOR AGONIST 8-OH-DPAT, Brain research, 640(1-2), 1994, pp. 223-228
The present study examined the behavioral responses of rats to unilate
ral and bilateral injections of the selective serotonin 1A (5-HT1A)-re
ceptor agonist 8-hydroxydipropylaminotetralin hydrobromide (8-OH-DPAT)
1 mug into the hippocampal CA1 area of male Wistar rats. 8-OH-DPAT in
creased locomotor activity, which was most pronounced with injections
into the left hippocampus. The agonist impaired learning and memory (s
huttle-box), especially when injected into the right hippocampus. The
elevated plus-maze experiments showed that neither left nor right nor
bilateral hippocampal injections of 8-OH-DPAT produced any anxiogenic
effect. However, with Vogel's conflict test, right injections of 8-OH-
DPAT produced anxiety. The present study has revealed hippocampal asym
metry in the behavioral responses to the 5-HT1A-receptor agonist 8-OH-
DPAT.