AUGMENTATION BY INTRACELLULAR ATP OF THE DELAYED RECTIFIER CURRENT INDEPENDENTLY OF THE GLIBENCLAMIDE-SENSITIVE K-CURRENT IN RABBIT ARTERIAL MYOCYTES

Authors
EVANS AM CLAPP LH GURNEY AM
Citation
Am. Evans et al., AUGMENTATION BY INTRACELLULAR ATP OF THE DELAYED RECTIFIER CURRENT INDEPENDENTLY OF THE GLIBENCLAMIDE-SENSITIVE K-CURRENT IN RABBIT ARTERIAL MYOCYTES, British Journal of Pharmacology, 111(4), 1994, pp. 972-974
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
British Journal of Pharmacology → ACNP
ISSN journal
00071188
Volume
111
Issue
4
Year of publication
1994
Pages
972 - 974
Database
ISI
SICI code
0007-1188(1994)111:4<972:ABIAOT>2.0.ZU;2-Y
Abstract
Elevation of intracellular ATP levels by flash photolysis of caged ATP augmented the delayed rectifier K-current (IKDR) in rabbit pulmonary artery myocytes. The percentage augmentation was unaffected when I(KDR ) was inactivated by 50% (holding potential - 40 mV), although the mag nitude of the ATP-induced current was substantially reduced. Inactivat ion of 90% I(KDR) (holding potential - 20 MV) virtually abolished the ATP-dependent augmentation. We conclude that modulation of I(KDR) by A TP does not require conversion of the glibenclamide-sensitive K-curren t (I(K(ATP))).