Sj. Farr et al., A GAMMA-SCINTIGRAPHIC STUDY OF TRACHEOBRONCHIAL DEPOSITION AND CLEARANCE OF NEBULIZED AEROSOLS, STP pharma sciences, 4(1), 1994, pp. 23-28
The importance of particle size in inhalation of nebulized aerosol was
investigated in healthy volunteers using gamma scintigraphy, Lung dep
osition was related to the percentage of particles below 5 mum for fiv
e different aerosols. Greater penetration of the distal airways was ac
hieved with aerosols of smaller sizes. The first order lung clearance
kinetics of Tc-99m-diethylenetriamine pentaacetate were similar for th
e different droplet sizes.