T. Kristmundsdottir et K. Ingvarsdottir, IBUPROFEN MICROCAPSULES - THE EFFECT OF PRODUCTION VARIABLES ON MICROCAPSULE PROPERTIES, Drug development and industrial pharmacy, 20(5), 1994, pp. 769-778
Ibuprofen was microencapsulated with ethylcellulose using the solvent
evaporation method. The effect of production variables on the properti
es of the microcapsules and drug release from them is described. Resul
ts show that size distribution, drug loading and the amount of free dr
ug on the surface of the microcapsules is affected by production varia
bles. The release of drug from the microcapsules was observed to be st
rongly influenced by parameters affecting the presence of uncoated dru
g on the microcapsule surface.