IBUPROFEN MICROCAPSULES - THE EFFECT OF PRODUCTION VARIABLES ON MICROCAPSULE PROPERTIES

Ibuprofen was microencapsulated with ethylcellulose using the solvent evaporation method. The effect of production variables on the properti es of the microcapsules and drug release from them is described. Resul ts show that size distribution, drug loading and the amount of free dr ug on the surface of the microcapsules is affected by production varia bles. The release of drug from the microcapsules was observed to be st rongly influenced by parameters affecting the presence of uncoated dru g on the microcapsule surface.