EFFECT OF AGING ON THE DISSOLUTION RATE OF NALIDIXIC-ACID TABLETS

Investigation of the dissolution rate profiles of nalidixic acid table ts of three commercial brands was carried out. Using the U.S.P. paddle method, significant inter-brand variations in dissolution rates were found and the tablets did not pass the U.S.P. dissolution test. The di ssolution of the tablets was also found to be adversely affected on ag ing. The observed differences in dissolution rates of the tablets exam ined were unrelated to their disintegration times. An attempt was made to improve the dissolution rate of nalidixic acid tablets through hyd rophilization of nalidixic acid powder and use of tablet excipients wi th high aqueous solubility were found to yield tablets of good physica l qualities which were unaffected on aging.