PREPARATION AND EVALUATION OF DIRECTLY-COMPRESSED INDOMETHACIN, INDOMETHACIN SODIUM AND INDOMETHACIN MEGLUMINE TABLETS

A formula containing Compactrol, Ac-Di-Sol,Aerosil 200 and talc was us ed to prepare directly-compressed tablets of indomethacin and its sodi um and meglumine salts. The prepared tablets were evaluated for unifor mity of weight and thickness, hardness, friability and content uniform ity. Each batch was then divided into two, one was coated with an opaq ue non-enteric film coat and evaluated for coat thickness uniformity. The dissolution rates of the uncoated and coated tablets and the effec t of shelf-storage, at room temperature for 11 months, on drug content s were also studied. Indomethacin meglumine tablets showed the least r elative standard deviation of weight and thickness. They exhibited acc eptable uniformity of content and coat thickness, and the highest hard ness-friability ratio. Also exhibited, uncoated and coated, the best i n-vitro release of its drug contents and the maximal stability.