CONFORMATIONAL STUDY OF A SERIES OF SOMATOSTATIN ANALOGS WITH ANTITUMOR AND OR GH INHIBITORY ACTIVITY/

A series of somatostatin analogues with varying activities have been s tudied by H-1 NMR in CD3OH at low temperature in order to find a possi ble structural explanation for the differentiation of biological activ ities. In somatostatin analogues with GH release inhibitory activity a beta-turn/beta-sheet backbone conformation is present, which is shown to be characteristic of somatostatin-derived peptides exhibiting this biological activity. On the other hand, among the analogues with anti tumor activity, a deviation from these typical structural features is clearly observed, but no general conformational model can be proposed. (C) Munksgaard 1994.