We retrospectively evaluated the factors which might have caused exces
sive corneal astigmatism after penetrating keratoplasty (PKP) in 29 ey
es, in which surgical correction of astigmatism was indicated. In 18 e
yes high astigmatism (5 diopters or more) existed before suture remova
l probably due to graft elevation (3x), wound dehiscence (3x), wound c
onfiguration abnormalities such as ovality/overcut (8x), and a thin re
cipient cornea (2x). The cause was unknown in 2 eyes. In 19 eyes the a
stigmatism considerably increased after all sutures were removed; asti
gmatism increased an average of 8.8 diopters (range, 5 to 16.5 D). Ten
of these 19 patients showed graft elevation, despite the fact that th
e sutures were only removed after an average 22.9 months. In 3 other p
atients the astigmatism gradually increased over the years, long after
suture removal; two of these showed graft elevation. The study demons
trates the possible instability of keratoplasty wounds, the change in
astigmatism after suture removal, and the late apparently spontaneous
changes in astigmatism after PKP in some eyes.