Objective: To review (1) Changes in cardiac impulse generation, conduc
tion, and ventricular filling in normal aging and disease; (2) Pacemak
er technology and nomenclature; (3) Expert guidelines about pacemaker
use; (4) Studies of pacemaker effectiveness and utilization. Design: A
rticles were identified through a Medline search, review of articles'
bibliographies, and contact with pacemaker manufacturer representative
s for information on device features and costs. These articles were re
viewed, and the relevant data are presented. Results: Abnormalities in
impulse generation and conduction are common in the elderly. Pacemake
r use is higher in the elderly than in other population groups. Hemody
namic changes associated with aging include an increased contribution
of atrial contraction to ventricular filling. Pacemakers, which mainta
in the synchrony between the atria and ventricles, may be particularly
advantageous in the elderly for this reason. Rate-responsive ventricu
lar pacemakers improve the quality of life compared with fixed rate de
vices in some patients over the age of 75. Dual-chamber, sequential pa
cemakers are more likely to reduce symptoms of pacemaker syndrome than
ventricular pacemakers and probably also prolong survival and reduce
risk of atrial fibrillation in certain groups of patients. However, du
al chamber devices are more expensive and require more frequent follow
-up. Pacemaker utilization can vary widely by region. Decisions about
pacemakers require explicit tradeoffs between risk and quality of life
on one hand and cost on the other. In many clinical situations, there
is controversy as to whether pacemakers should be used. Conclusions:
Pacemakers provide definite benefits to some patients, whereas in othe
rs, the likelihood of benefit is uncertain. More sophisticated devices
may provide some additional benefit, but they are more costly. Furthe
r data is still required to define precisely which groups of patients
substantially benefit from complex and expensive pacing modalities com
pared with simpler ones.