P. Backman et al., HEAT-CONDUCTION CALORIMETERS - TIME CONSTANTS, SENSITIVITY AND FAST TITRATION EXPERIMENTS, Journal of biochemical and biophysical methods, 28(2), 1994, pp. 85-100
Seven heat conduction calorimeters have been evaluated in terms of sen
sitivity and thermal response time. The use of a dynamic method to cor
rect for the thermal inertia of the calorimeter is shown to reduce by
one order of magnitude the time required to conduct a stepwise titrati
on experiment involving a fast reaction. The ability to determine asso
ciation constants of strong 1:1 complexes has been evaluated in terms
of the precision of determining thermal energy.