A prospective clinical trial was conducted involving patients with pro
lapsed lumbar intervertebral disk proven myelographically, who had ant
erior diskectomy and disk replacement with a titanium-mesh block impla
nt. A pilot study was done in 1971 on six patients. In this trial, 28
patients were operated on with informed consent. Twenty-three had a mi
nimum of five years' follow-up study. There were 14 men and boys, and
nine women and girls. The average follow-up period was eight years and
four months (range, five to 12 years three months). The average age a
t operation was 36 years four months (range, 13-66 years). Symptomatic
improvement were divided into three groups. Sixteen patients were in
Group 1, three in Group 2, and three in Group 3. Flexion-extension rad
iographs showed 14 patients with no movement between the vertebral bod
ies adjacent to the operated disk, five with minimal movement, and fou
r with definite movement. At the implant-bone interface, no radiolucen
t zone was seen in 18 patients, and a definite radiolucent zone was se
en in five. Twenty implants were intact, three implants had developed
a crack, and three were deformed. There were no complications. The tit
anium-mesh block implant is an effective substitute for autogenous bon
e grafting in interbody fusion.