THE REGULARITY OF CHANGES OF THE CHOU-FASMAN PARAMETERS WITHIN THE GENETIC-CODE

It has been shown that Chou-Fasman conformational parameters of amino acids, which reflect their ability to adopt a definite conformation wi thin the peptide chain, change very regularly within the genetic code, arranged in the manner discussed recently by Siemion and Stefanowicz (1992a) (BioSystems 27, 77-84). Two mutually perpendicular C, axes of pseudosymmetry appear in the center of the diagrams (between ACY and A CR threonine codons) presenting the changes of P, and Pg parameters, T he left and right parts of diagrams superimpose on each other quite we ll when the symmetry operation involving a proper axis is performed. T his phenomenon is due, in our opinion, to the regular arrangement of e quivalent codons in the 'one-step mutation' ring formed by 64 triplets of the genetic code.