LIPOPROTEIN(A) AND ATHEROGENESIS

Authors
LIU AC LAWN RM
Citation
Ac. Liu et Rm. Lawn, LIPOPROTEIN(A) AND ATHEROGENESIS, Trends in cardiovascular medicine, 4(1), 1994, pp. 40-44
Citations number
53
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Trends in cardiovascular medicine → ACNP
ISSN journal
10501738
Volume
4
Issue
1
Year of publication
1994
Pages
40 - 44
Database
ISI
SICI code
1050-1738(1994)4:1<40:LAA>2.0.ZU;2-S
Abstract
Lipoprotein(a) is a major inherited risk factor for atherosclerosis. M any of ifs activities depend on ifs plasminlike component, apolipoprot ein(a). In vitro studies suggest that apolipoprotein(a) could enhance lipid deposition through binding to sites in the vessel wall, interfer e with fibrinolysis, and modulate smooth muscle cell activity. Human a nd animal studies will be necessary to establish the physiologic impor tance of these mechanisms.