SUPERANTIGENS AND RETROVIRAL INFECTION - INSIGHTS FROM MOUSE MAMMARY-TUMOR VIRUS

Authors
HELD W ACHAORBEA H MACDONALD HR WAANDERS GA
Citation
W. Held et al., SUPERANTIGENS AND RETROVIRAL INFECTION - INSIGHTS FROM MOUSE MAMMARY-TUMOR VIRUS, Immunology today, 15(4), 1994, pp. 184-190
Citations number
55
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
15
Issue
4
Year of publication
1994
Pages
184 - 190
Database
ISI
SICI code
0167-5699(1994)15:4<184:SARI-I>2.0.ZU;2-T
Abstract
Superantigens induce a vigorous immune response by stimulating T cell' s that express particular T-cell receptor Vbeta chains. Mouse mammary tumor virus is a milk-transmitted retrovirus that encodes such a super antigen. Paradoxically, as discussed by Werner Held and colleagues, th e strong superantigen-induced immune response permits the survival of the virus via T-cell dependent clonal expansion of infected B cells.