E. Razis et al., TREATMENT OF GANCYCLOVIR RESISTANT CYTOMEGALOVIRUS WITH FOSCARNET - AREPORT OF 2 CASES OCCURRING AFTER BONE-MARROW TRANSPLANTATION, Leukemia & lymphoma, 12(5-6), 1994, pp. 477-480
Cytomegalovirus (CMV) infection is common in patients who undergo allo
geneic bone marrow transplantation. Gancyclovir is useful in treating
CMV infections. Resistance to gancyclovir is rare and has, thus far, n
ot been reported in the setting of BMT. Two patients with CMV infectio
ns unresponsive to gancyclovir were successfully treated with foscarne
t. 1015% of CMV infections are resistant initially or develop resistan
ce to gancyclovir. Both patients had an adequate trial of gancyclovir
and resistance developed over time. While we did not document resistan
ce in the laboratory there was dramatic clinical improvement with fosc
arnet.