We retrospectively compared the use of primary elective open sternum c
oupled with delayed sternal closure with the;use of primary sternal cl
osure in neonates after cardiac operations. Primary elective open ster
num/delayed sternal closure was selectively used in patients who demon
strated hemodynamic or respiratory deterioration, or both, during an i
ntraoperative trial of sternal closure; otherwise primary sternal clos
ure was used. Primary elective open sternum was used in 55 (61.8%) and
primary sternal closure in 34 (38.2%) of the 89 patients studied. Ele
ven (20%) patients having primary elective open sternum died compared
with 5 (14.7%) patients having primary sternal closure (p = 0.6). Six
(10.9%) of the patients with primary elective open sternum died before
delayed sternal closure; the remaining 49 patients comprise the prima
ry elective open sternum/delayed sternal closure group. The durations
of mechanical ventilation (9.7 +/- 0.9 days [mean plus or minus standa
rd error of the mean], median 7.7 versus 9.9 +/- 3.4 days, median 4.9;
p = 0.0005) and hospital stay (21.1 +/- 1.4 days, median 17.7 versus
19.6 +/- 4.1 days, median 12.9; p = 0.004) were shorter in the primary
sternal closure group. The overall. morbidity and duration of inotrop
ic support were not significantly different between the two groups, al
though seven (20.6%) of the patients with primary sternal closure did
have to undergo delayed sternal reopening for refractory postoperative
low cardiac output. There was one superficial wound infection in the
primary elective open sternum/delayed sternal closure group. Primary e
lective open sternum/delayed sternal closure is an effective treatment
for postoperative neonatal mediastinal compression for the following
reasons: (1) the morbidity is low; (2) the mortality of the critically
ill group of neonates in whom primary elective open sternum/delayed s
ternal closure was used was similar to that of the less critically ill
primary sternal closure group; and (3) 20.6% of the primary sternal c
losure group eventually had to undergo delayed sternal reopening to tr
eat refractory postoperative low cardiac output.