Ty. Goryunova et al., USE OF H-3 TAGGED PERMETRINE TO STUDY MECHANISMS OF PESTICIDE RESISTANCE IN RESISTANT AND SENSITIVE STRAINS OF HOUSEFLY, Eurasian soil science, 25(8), 1993, pp. 117-125
The use of highly radioactive tritium-tagged permetrine (1.5 Ci/mmol)
to study the uptake of the pesticide by sensitive and resistant strain
s of housefly (with LD50 of 2 and 22 ppm, respectively) and its metabo
lism is described. The dynamics of the uptake, metabolism, and excreti
on of permetrine are determined. The high radioactivity of the tagged
pesticide made it possible to analyze individual specimens. The resist
ance of the R strain results from low permeability of the cuticle and
a high rate of metabolism of permetrine. The methods described can be
used to study mechanisms of resistance and to monitor the development
of resistance in natural populations.