RELATIONSHIPS BETWEEN MATERNAL AND FETAL LIVER COPPER, IRON, MANGANESE, AND ZINC CONCENTRATIONS AND FETAL DEVELOPMENT IN CALIFORNIA HOLSTEIN DAIRY-COWS
Tw. Graham et al., RELATIONSHIPS BETWEEN MATERNAL AND FETAL LIVER COPPER, IRON, MANGANESE, AND ZINC CONCENTRATIONS AND FETAL DEVELOPMENT IN CALIFORNIA HOLSTEIN DAIRY-COWS, Journal of veterinary diagnostic investigation, 6(1), 1994, pp. 77-87
Associations between maternal trace element deficiencies and abortion
have been made for many mammalian species. Objectives of this study we
re to estimate and correlate maternal and fetal hepatic Cu, Fe, Mn, an
d Zn concentrations through gestation. Additionally, aborted fetuses,
stratified by cause of abortion (infectious or noninfectious), were co
mpared to size-matched nonaborted fetuses to examine for magnitude and
direction of change in hepatic trace element status. Dam and fetal li
ver were removed at slaughter from 103 Holstein dairy cows judged gros
sly normal by ante- and postmortem examination. Liver samples were col
lected from fetuses submitted by veterinarians for routine diagnosis o
f abortion (n = 80). Hepatic Cu, Fe, Mn, and Zn concentrations were de
termined by flame spectrophotometry. Comparisons of groups, estimation
s of correlations, and derived prediction equations were made by least
-squares methods. Maternal liver Cu, Fe, Mn, and Zn concentrations did
not vary during gestation. Compared with the dam, fetal liver Fe and
Zn concentrations were higher (P < 0.05), fetal Cu concentrations were
similar (P > 0.05), and fetal liver Mn concentrations were lower (P <
0.05). As fetal size increased, fetal liver Cu and Zn concentrations
increased (P < 0.05), fetal liver Fe concentration decreased (P < 0.05
), and fetal liver Mn did not change (P > 0.05). Aborted fetuses had l
ower liver Cu, Mn, and Zn concentrations than did nonaborted fetuses (
P < 0.05). Liver Fe concentration was lower in aborted fetuses than in
nonaborted fetuses in the second trimester only (P < 0.05). Consisten
tly lower liver Cu, Fe, Mn, and Zn concentrations in aborted fetuses s
uggest a nonspecific change in trace element status, which implies an
effect of abortion, not a cause of abortion.