MDX MOUSE SKELETAL-MUSCLE - COULD A MITOCHONDRIAL FACTOR BE RESPONSIBLE FOR THE ABSENCE OF PROGRESSIVE NECROSIS

We compared the myotoxic effect of chlorpromazine on mitochondria of g astrocnemius muscle in X-related muscular dystrophy (mdx) and control mice relative to changes in calmitine and calcium concentrations befor e and 3 and 6 days after a single injection of the drug. The results i ndicate that mdx mouse mitochondria are less sensitive to the myotoxic effect of chlorpromazine; calmitine and calcium binding were only sli ghtly reduced compared to controls. Our observations indicate that the calmitine structure could differ in mdx and control mice with respect to calcium binding structures, and that the presence of calmitine in the mitochondria of mdx mouse skeletal muscle could explain why muscle degeneration does not occur in these animals. However, the muscles of patients with Duchenne muscular dystrophy (DMD) are lacking in calmit ine and are subject to extensive progressive degeneration.