SUBSTITUTED 2-AMINONICOTINONITRILES

Authors
TROSCHUTZ R DENNSTEDT T
Citation
R. Troschutz et T. Dennstedt, SUBSTITUTED 2-AMINONICOTINONITRILES, Archiv der pharmazie, 327(2), 1994, pp. 85-89
Citations number
14
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
327
Issue
2
Year of publication
1994
Pages
85 - 89
Database
ISI
SICI code
0365-6233(1994)327:2<85:S2>2.0.ZU;2-Y
Abstract
Aminolysis of the cyanoketene-O,N-acetal 1 Z/E with the amines 2a,b le ads to the E-configurated cyanoketeneaminals 3a,b. Compounds 3a,b are reacted with 1,3-biselectrophiles 4, 6a,b, 9 HCl, 12, 13, 15a,b, 17, a nd 19 to yield the N-2-substituted 2-aminonicotinonitriles 5, 7, 8, 10 , 11, 14, 16, and 20. Reaction of some 2-aminonicotinonitriles with an ol-phenylethyl substituent in position 2 (14b, 16a, 8a, 20b, 5 and 8b ) with PPA leads to the primary 2-aminonicotinonitriles 21a-f.