SYNTHESIS OF ANTITUMOR CARBON-BRIDGED IMIDAZOPYRIDAZINE CARBAMATES

Authors
DENYER CV REDDY MT JENKINS DC RAPSON E WATTS SDM
Citation
Cv. Denyer et al., SYNTHESIS OF ANTITUMOR CARBON-BRIDGED IMIDAZOPYRIDAZINE CARBAMATES, Archiv der pharmazie, 327(2), 1994, pp. 95-98
Citations number
12
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
327
Issue
2
Year of publication
1994
Pages
95 - 98
Database
ISI
SICI code
0365-6233(1994)327:2<95:SOACIC>2.0.ZU;2-D
Abstract
Two carbon-bridged analogues 11 and 15 of the potent microtubule inhib itor BW1069C85 (1) have been synthesised and evaluated for antitubulin and antitumour activity in vitro. Though the compounds were somewhat less potent than BW1069C85, significant activity against tubulin polym erisation and cell proliferation was demonstrated in the assays.