RENAL TOLERANCE OF GADOLINIUM-DOTA AND GADOLINIUM-DTPA IN RATS

RATIONALE AND OBJECTIVES. Although gadolinium chelates are mainly elim inated by the kidney, there is limited information about their effects . The renal tolerance of these compounds on renal function in an in vi vo rat model are evaluated. METHODS. A combination of renal ischemia a nd intrarenal iodinated contrast agent infusion (diatrizoate) led to a reproducible and reversible model of acute renal failure (n = 5). Usi ng this model, the renal tolerance of gadolinium DOTA (Gd-DOTA) (n = 1 0) and gadolinium DTPA (Gd-DTPA) (n 10) were evaluated. The effects of the association of Gd-DOTA with diatrizoate (n = 5) on renal function also were assessed. RESULTS. Gadolinium DOTA induced no change in ser um creatinine and creatinine clearance. Gadolinium DTPA induced a sign ificant increase in serum creatinine (50 to 83 +/- 5 and 70 +/- 6 mu m ol/L) before and at 24 and 48 hours, respectively (P < .05), and a dec rease in creatinine clearance from 1.6 +/- 0.1 to 0.8 +/- 0.1; 1,2 +/- 0.1 mL/mL before and at 24 and 48 hours, respectively (P < .05). In t his model, Gd-DOTA did not modify the renal tolerance of diatrizoate a s assessed with serum creatinine and creatinine clearance. CONCLUSIONS . Gadolinium DOTA is not nephrotoxic and can be infused in association with iodinated contrast media. In this model, Gd-DTPA induced reversi ble renal failure.