TIBIAL HEMIMELIA AND TETRALOGY OF FALLOT ASSOCIATED WITH FIRST TRIMESTER EXPOSURE TO AMANTADINE

Authors
PANDIT PB CHITAYAT D JEFFERIES AL LANDES A QAMAR IU KOREN G
Citation
Pb. Pandit et al., TIBIAL HEMIMELIA AND TETRALOGY OF FALLOT ASSOCIATED WITH FIRST TRIMESTER EXPOSURE TO AMANTADINE, Reproductive toxicology, 8(1), 1994, pp. 89-92
Citations number
26
Categorie Soggetti
Reproductive Biology",Toxicology
Journal title
Reproductive toxicology → ACNP
ISSN journal
08906238
Volume
8
Issue
1
Year of publication
1994
Pages
89 - 92
Database
ISI
SICI code
0890-6238(1994)8:1<89:THATOF>2.0.ZU;2-6
Abstract
Although amantadine hydrochloride has been extensively used for the pr evention of influenza A2, few data exist regarding its safety in pregn ancy. We report the outcome of a pregnancy during which the mother was treated with amantadine in the first trimester. The infant, born at 2 9 weeks gestation, has tetralogy of Fallot and tibial hemimelia. Follo w-up of the four prospective cases known to date to the Motherisk Prog ram in Toronto did not identify any abnormalities.