SYNTHESIS OF RPR-100893, PROTOTYPE OF A NEW SERIES OF POTENT AND SELECTIVE NON PEPTIDE NK1 ANTAGONISTS - THE TRIARYLPERHYDROISOINDOLOLS

Authors
TABART M PEYRONEL JF
Citation
M. Tabart et Jf. Peyronel, SYNTHESIS OF RPR-100893, PROTOTYPE OF A NEW SERIES OF POTENT AND SELECTIVE NON PEPTIDE NK1 ANTAGONISTS - THE TRIARYLPERHYDROISOINDOLOLS, Bioorganic & medicinal chemistry letters, 4(5), 1994, pp. 673-676
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
5
Year of publication
1994
Pages
673 - 676
Database
ISI
SICI code
0960-894X(1994)4:5<673:SORPOA>2.0.ZU;2-8
Abstract
The synthesis of enantiomerically pure RPR 100893, a novel non peptide NKI Substance P antagonist, is descfibed. This compound is a represen tative of 7,7,4-tfiaryl perhydroisoindol-4-ols, a new sefies of perhyd roisoindole Substance P antagonists with high affinity for human NK1 r eceptor.