M. Tabart et Jf. Peyronel, SYNTHESIS OF RPR-100893, PROTOTYPE OF A NEW SERIES OF POTENT AND SELECTIVE NON PEPTIDE NK1 ANTAGONISTS - THE TRIARYLPERHYDROISOINDOLOLS, Bioorganic & medicinal chemistry letters, 4(5), 1994, pp. 673-676
The synthesis of enantiomerically pure RPR 100893, a novel non peptide
NKI Substance P antagonist, is descfibed. This compound is a represen
tative of 7,7,4-tfiaryl perhydroisoindol-4-ols, a new sefies of perhyd
roisoindole Substance P antagonists with high affinity for human NK1 r
eceptor.