SYNTHESIS AND CRYSTAL-STRUCTURE OF 3'-FLUORO-3'-METHYL-2',3'-DIDEOXYTHYMIDINE - INHIBITORY PROPERTIES OF O-3'-METHYL-2',3'-DIDEOXYTHYMIDINE-5'-TRIPHOSPHATE IN THE SYNTHESIS OF DNA IN CELL-FREE MEDIA

Authors
SHUTALEV AD MIKERIN IE ARSHAVA BM NIKITENKO AA RAIFELD YE YAVID G LEE VJ GURSKAYA GV VIKTOROVA LS JASKO MV SEMIZAROV DG ZAVODNIK VE
Citation
Ad. Shutalev et al., SYNTHESIS AND CRYSTAL-STRUCTURE OF 3'-FLUORO-3'-METHYL-2',3'-DIDEOXYTHYMIDINE - INHIBITORY PROPERTIES OF O-3'-METHYL-2',3'-DIDEOXYTHYMIDINE-5'-TRIPHOSPHATE IN THE SYNTHESIS OF DNA IN CELL-FREE MEDIA, Bioorganic & medicinal chemistry letters, 4(5), 1994, pp. 761-768
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
5
Year of publication
1994
Pages
761 - 768
Database
ISI
SICI code
0960-894X(1994)4:5<761:SACO3>2.0.ZU;2-C
Abstract
The synthesis, physicochemical properties and chain-termination proper ties of 3'-fluoro-3'-methyl-2',3'-dideoxythymidine is described. The s ynthesis was accomplished by the coupling of bis(TMS)thymine with 3-fl uoro-3-methyl-2,3-dideoxy-D-erythro-pentose which is obtained from non -carbohydrate precursors.