Aa. Kilkichko et al., MUTAGENIC EFFECT OF N-NITROSODIMETHYLAMIN E SYNTHESIS PRECURSORS IN AMES TEST, Eksperimental'naa onkologia, 15(6), 1993, pp. 25-28
Mutagenic effects of N-nitrosodimethylamine (NDMA) precursors: sodium
nitrite (SN), dimethylamine (DMA) and amidopyryne (AP), have been stud
ied in the Ames test. Administration of SN caused strong mutagenic eff
ect in Salmonella typhimurium TA 100, amines had no mutagenic activity
. Mutagenic effect of mixtures SN and DMA or SN and AP differed depend
ing on the properties of nitrosable precursor. In the agar medium NDMA
was found (0.03-4.0 mg/l). Concentration of the formed carcinogen was
inversely proportional to the mutagenic effect in the same Petri plat
e. In complex mixtures containing both nitrosamines and their precurso
rs the mutagenic effect of SN may predominate.