ALTERATIONS OF ERBB-1 (HER-1), ERBB-2 (HER-2 NEU), C-MYC AND HRAS-1 ONCOGENES, P53 AND RB-1 SUPPRESSOR GENES, AND LOSSES OF GENETIC MATERIAL AT THE CHROMOSOME-17 IN HUMAN OVARIAN CARCINOMAS/

Authors
IMYANITOV EN CHERNITSA OI NIKIFOROVA IF SEROVA OM SOKOLOV SI YURKOVA LE VINOKUROV VL TOGO AV KNYAZEV PG
Citation
En. Imyanitov et al., ALTERATIONS OF ERBB-1 (HER-1), ERBB-2 (HER-2 NEU), C-MYC AND HRAS-1 ONCOGENES, P53 AND RB-1 SUPPRESSOR GENES, AND LOSSES OF GENETIC MATERIAL AT THE CHROMOSOME-17 IN HUMAN OVARIAN CARCINOMAS/, Eksperimental'naa onkologia, 15(6), 1993, pp. 41-43
Citations number
24
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
15
Issue
6
Year of publication
1993
Pages
41 - 43
Database
ISI
SICI code
0204-3564(1993)15:6<41:AOE(E(>2.0.ZU;2-D
Abstract
Abnormalities of some genetic loci were studied in ovarian carcinomas (OC). Amplification of ERBB-2 oncogene was detected in 1 of 36 cases; ERBB-1 - in 1 of 26; C-MYC - in none of 26. Loss of heterozygosity (LO H) of HRAS-1 oncogene (chromosome 11p) was observed in 5 of 17 informa tive cases. Distribution of HRAS-1 alleles in OC patients was not dras tically differ from healthy donors. Southern-blot analysis revealed no abnormalities of RB-1 (25 cases) and p53 (36 cases) antioncogenes. LO H at chromosome 17p (probe YNZ-22) was found in 7 of 13 heterozygous O C; 17q (probe THH-59) -in 9 of 21. Further investigations are necessar y to clarify the molecular pathogenesis of ovarian malignancies.