STUDY OF ANTITUMOR-ACTIVITY OF THE DEVELO PING BRAIN-CELLS TRANSPLANTED JOINTLY WITH LEWIS LUNG-CARCINOMA INFRACAPSULARLY IN THE KIDNEY OF CBA MICE

Mechanisms promoting inhibition of the Lewis, carcinoma growth by the developing brain cells (embryo and newborn brains) simultaneously tran splanted infracapsularly in the kidney of CBA mice have been studied. The immune-like properties of neurons and glial cells of the developin g brain were analyzed (the expression of Lyt-1, Lyt-2, L3T4 antigens, spontaneous cytotoxicity of neurons and glia, etc.). It was establishe d that cells of the developing brain enriched in neurons showed a more significant activity inhibiting the tumor growth. The cells which exp ress Lyt-2 antigens are more frequently revealed among the neurons, bu t they do not possess spontaneous cytotoxicity unlike neuroglial cells . Neurons and glial cells modulate spontaneous cytotoxicity of splenoc ytes. The obtained data extend knowledge on availability of immune-lik e functions of nerve cells.