STUDY OF THE PATHOMORPHOLOGICAL CHANGES A ND HORMONAL RECEPTORS OF WOMAN BREAST-CANCER AFTER ABORTION, IN PREGNANCY AND LACTATION

The pathomorphological study of 52 samples of woman breast cancer was carried out after abortion, in pregnancy and lactation. At the same ti me cytoplasmic estrogen (ER) and progesterone receptors (PgR) were stu died in 41 tumours and expression of beta-casein gene in 9 tumours. So me morphometric peculiarities of tumours were established in pregnant women. The prevalence of invasive intraductal forms, moderate and low differentiation of tumour cells, frequent secretion of tumour cells ch aracterized by high expression of beta-casein genes. The degree of tum our differentiation in the breast cancer correlates greately with the alterations of estrogen receptors' contents in tumours, rather than wi th progesterone.