DIFFERENTIAL-PULSE POLAROGRAPHIC-DETERMINATION OF DITHRANOL FROM CREAM PHARMACEUTICAL PREPARATION

A method has been developed to analyze dithranol by using differential pulse polarography. The method developed was applied to a cream pharm aceutical preparation and compared with an official method. Electroana lytical studies show that a peak at -1.78 V vs. Ag/AgCl reference elec trode in 0.05 M Et(4)NI solution can be used for the analysis of dithr anol in the range of 0.2-6.5 ppb. A method for the analysis of dithran ol has been applied to a cream pharmaceutical preparation after an ext raction procedure. The liquid-liquid extraction has been accomplished by using chloroform. The recovery has been found to be 98% with a rela tive standard deviation of 2.70%.