A. Temizer et al., DIFFERENTIAL-PULSE POLAROGRAPHIC-DETERMINATION OF DITHRANOL FROM CREAM PHARMACEUTICAL PREPARATION, Analytical letters, 27(4), 1994, pp. 717-722
A method has been developed to analyze dithranol by using differential
pulse polarography. The method developed was applied to a cream pharm
aceutical preparation and compared with an official method. Electroana
lytical studies show that a peak at -1.78 V vs. Ag/AgCl reference elec
trode in 0.05 M Et(4)NI solution can be used for the analysis of dithr
anol in the range of 0.2-6.5 ppb. A method for the analysis of dithran
ol has been applied to a cream pharmaceutical preparation after an ext
raction procedure. The liquid-liquid extraction has been accomplished
by using chloroform. The recovery has been found to be 98% with a rela
tive standard deviation of 2.70%.