INFLUENCES OF AGING AND SEX ON RENAL PELVIC CARCINOGENESIS BY N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE IN NON SHI MICE/

Influences of aging and sex on renal pelvic carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) were examined in 6-, 15- a nd 45-week-old male and female NON/Shi mice. Histopathological examina tion revealed an age-related shortening of induction time for renal pe lvic carcinomas in males, although actual incidences did not increase. The histological patterns of carcinomas induced in both renal pelvis and urinary bladder demonstrated male mice to be more prone to develop transitional cell carcinomas, while squamous cell carcinomas were mor e likely to arise in females. Moreover, the sex factor appeared to inf luence the progression of both renal pelvic and urinary bladder carcin omas.