LOCAL-DELIVERY OF PROSTAGLANDIN E(1) INDUCES PERIODONTAL REGENERATIONIN ADULT DOGS

Formation of cementum, alveolar bone and periodontal ligament was prod uced in 18 sites on buccal surfaces of mandibular premolars and molars of 11 adult dogs near to sites of local delivery of prostaglandin E(1 ) (PGE) for three weeks. Mineralizing bone and cementum were labelled with fluorescent dyes and polarizing microscopy showed periodontal lig ament fibers between these new mineralized tissues. These observations extend recent demonstrations that local application of PGE causes for mation of new bone on the mandible and suggest the potential for predi ctable, site-directed periodontal regeneration.