EFFECTS OF NITRIC-OXIDE ON RED-BLOOD-CELLS - CHANGES IN ERYTHROCYTE RESISTANCE TO HYPOTONIC HEMOLYSIS AND POTASSIUM EFFLUX BY EXPERIMENTAL MANEUVERS THAT DECREASE NITRIC-OXIDE

Authors
CARAMELO C RIESCO A OUTEIRINO J MILLAS I BLUM G MONZU B CASADO V SANCHEZ L MOSQUERA JR CASADO S FARRE AL
Citation
C. Caramelo et al., EFFECTS OF NITRIC-OXIDE ON RED-BLOOD-CELLS - CHANGES IN ERYTHROCYTE RESISTANCE TO HYPOTONIC HEMOLYSIS AND POTASSIUM EFFLUX BY EXPERIMENTAL MANEUVERS THAT DECREASE NITRIC-OXIDE, Biochemical and biophysical research communications, 199(2), 1994, pp. 447-454
Citations number
22
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
199
Issue
2
Year of publication
1994
Pages
447 - 454
Database
ISI
SICI code
0006-291X(1994)199:2<447:EONOR->2.0.ZU;2-T
Abstract
To determine the role of nitric oxide (NO)-dependent mechanisms on ery throcyte properties, we exposed red cells to L-arginine competitive an alogues, 8Br-cyclic guanosine monophosphate (8Br-cGMP) and neutrophil- eliminating filters. These treatments significantly decreased hypotoni c hemolysis, increased potassium efflux and caused a spiculate change in erythrocyte morphology. These effects were related to a decrease of NO caused by the three types of treatments. (C) 1994 Academic Press, Inc.