A NEW HUMAN SLOW SKELETAL TROPONIN-T (TNTS) MRNA ISOFORM DERIVED FROMALTERNATIVE SPLICING OF A SINGLE-GENE

Authors
SAMSON F MESNARD L MIHOVILOVIC M POTTER TG MERCADIER JJ ROSES AD GILBERT JR
Citation
F. Samson et al., A NEW HUMAN SLOW SKELETAL TROPONIN-T (TNTS) MRNA ISOFORM DERIVED FROMALTERNATIVE SPLICING OF A SINGLE-GENE, Biochemical and biophysical research communications, 199(2), 1994, pp. 841-847
Citations number
13
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
199
Issue
2
Year of publication
1994
Pages
841 - 847
Database
ISI
SICI code
0006-291X(1994)199:2<841:ANHSST>2.0.ZU;2-F
Abstract
A human muscle cDNA library was screened for slow skeletal troponin T (TnTs). Sequence analysis revealed that one of the selected clones had a cDNA coding sequence different from the two previously described. R Nase protection assays confirmed the expression of this new isoform in adult skeletal muscle. In addition, results of the RNase protection a ssays strongly suggested the expression of a fourth isoform. These iso forms for human slow TnT most likely result from combinatorial alterna tive splicing of a single gene. (C) 1994 Academic Press, Inc.