ENANTIOSELECTIVE SYNTHESIS OF 1,3-DIOXYGEN-SUBSTITUTED CHIRAL BUILDING-BLOCKS

Authors
SENANAYAKE CH LARSEN RD BILL TJ CORLEY EG REIDER PJ
Citation
Ch. Senanayake et al., ENANTIOSELECTIVE SYNTHESIS OF 1,3-DIOXYGEN-SUBSTITUTED CHIRAL BUILDING-BLOCKS, Synlett, (3), 1994, pp. 199-200
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
3
Year of publication
1994
Pages
199 - 200
Database
ISI
SICI code
0936-5214(1994):3<199:ESO1CB>2.0.ZU;2-U
Abstract
The extremely useful chiral building blocks 3-hydroxy-2-alkylpropionat es 8 are prepared in either S or R enantiomeric form via the diastereo selective addition of chiral alcohols to arylketenes 4 and the manipul ation of the resultant chiral 2-arylaliphatic esters 5 and 6. Applicat ion of this methodology to the asymmetric syntheses of 3-mercapto-2-al kylpropionates (9) and (S)-(-)-paraconic acid (3) is described.