DETERMINATION OF THE ANTIISCHEMIC ACTIVITY OF NEBIVOLOL IN COMPARISONWITH ATENOLOL

Citation
G. Ruf et al., DETERMINATION OF THE ANTIISCHEMIC ACTIVITY OF NEBIVOLOL IN COMPARISONWITH ATENOLOL, International journal of cardiology, 43(3), 1994, pp. 279-285
Citations number
17
Categorie Soggetti
Cardiac & Cardiovascular System
ISSN journal
01675273
Volume
43
Issue
3
Year of publication
1994
Pages
279 - 285
Database
ISI
SICI code
0167-5273(1994)43:3<279:DOTAAO>2.0.ZU;2-2
Abstract
The anti-ischemic effect of 5 mg nebivolol o.i.d., a newly developed b eta1-selective adrenoceptor blocking drug with vasodilating properties , was compared with that of atenolol (100 mg o.i.d.) following a treat ment period of 6 days. The study was performed in 24 patients with doc umented coronary artery disease and stable angina pectoris according t o a double-blind randomized study, designed using conventional symptom -limited exercise testing. Exercise testing 3 h after the first dose s howed a more marked ST-segment reduction by atenolol than by nebivolol (59% vs. 18%). ST-segment depression measured 24 h after administrati on of the penultimate dose was statistically significantly reduced by nebivolol (from 0.19 +/- 0.07 to 0.13 +/- 0.07 mV; P = 0.0059) but not by atenolol (from 0.17 +/- 0.06 to 0.14 +/- 0.10 mV; P = 0.0703). App roximately 3 h after the last dose, the reduction was comparable (45% and 38% by nebivolol and atenolol, respectively). Exercise duration, e xercise time necessary to produce ST-segment depression by 0.1 mV and exercise time to the onset of angina were also prolonged following adm inistration of both drugs. Thus, at steady-state single daily doses of 100 mg atenolol and 5 mg nebivolol were about equieffective when meas ured at time of maximal effect (i.e. 3 h after drug administration). H owever, duration of action with respect to the ST-segment depression s eems to be slightly longer for nebivolol.