K. Katayama et al., SUCCESSFUL PERITRANSPLANT THERAPY IN CHILDREN WITH ACTIVE HEPATOSPLENIC CANDIDIASIS, International journal of hematology, 59(2), 1994, pp. 125-130
Two pediatric leukemic patients with hepatosplenic candidiasis during
multidrug antileukemic chemotherapy successfully underwent bone marrow
transplantation (BMT) after aggressive antifungal chemotherapy employ
ing fluconazole and amphotericin B with or without splenectomy. One pa
tient received allogeneic marrow graft and the other received an autol
ogous graft. One patient has been disease-free for more than 21 months
after BMT without any recurrence of Candida infection. The other pati
ent showed tentative reactivation of hepatic lesions just after BMT by
CT scanning, but these lesions disappeared again by continuous admini
stration of the antifungal agents. The second patient died of leukemia
relapse without recurrence of fungal infection. Our cases indicate th
e possibility of successful BMT once a fungal infection is well contro
lled by antifungal chemotherapy and surgical resection.